The Role Of Regulatory Factor On Genomic Dna - 2322 Words

INTRODUCTION Regulatory factor is bound with genomic DNA to protect the sequence from cleavage through DNase I. With the help of DNase I, it is easy to identify the 41 diverse cells with nucleotide resolution. Around 45 million transcription factors are detected in the regulatory regions. They represent the binding to the elements that are of short sequence. Genetic variations affect the allelic chromatin which is present in concentrated manner in the footprints. But these variations effects are enclosed by the DNA methylation. Regulatory factor which is bound to genomic DNA mainly protects the underlying sequence from the cleavage by DNase I and leaving the nucleotide-resolution footprints (Galas, D. J. Schmitz, A. DNAse foot†¦show more content†¦They enable the discovery of the human transcription factors. Transcription factors are bound to regulate the DNA instead of canonical nucleosomes. The foot printing is followed by the DNase I so as to understand the basics of transcription fac tors. In this research the regulatory DNA is populated with the DNase I footprints. When the DNase I and regulatory DNA are mapped together, digital genomic footprints are found. To sort out these footprints, they are interdependent on the density of the DNA cleavages. A large collection of the novel regulatory factor recognise the motifs which are highly conserved in both sequence and function they also exhibit the cell-selective occupancy patterns which are closely parallel to major regulators of development, differentiation and pluripotency (Dynan, W. S. Tjian, R. The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. Cell 35, 79–87 (1983)). RESULTS Parallel profiling of genomic regulatory factor occupancy across 41 cell types In this figure 1a, the DNase I performed the foot printing of K562 cells, they identify an individual nucleotide in the MTPN promoter. These promoters are bound by NRF1.In figure 1b, 8 defined

Children with Special Needs in Education - 1079 Words

Special (adj.): better, greater, or otherwise different from what is usual. Children with special needs have some form of disability whether that be a learning, behavioral, physical, or emotional disability. These children need certain accommodations to help them reach their academic and social goals in school. There are many different types of disabilities, Dyslexia, Attention Deficit Hyperactive Disorder, Mental retardation, Autism Spectrum Disorders, and each one has a completely different effect on the individual. Their disability does not define them as human being but rather adds to their uniqueness. Children with special needs are like every other child who loves to play, explore, and let their imaginations run wild. The term simply means that student in particular needs more of an individualized curriculum and learning techniques to help them reach their full potential. Beginning in the early 1900’s, a small number schools were created in America to the â€Å"educab le mentally retarded†. Many of these facilities were boarding schools where students were sent for weeks to months away from their families to achieve this education. At this point in time, there was no academic alternative for children with disabilities to learn. In 1922 the Council for Exceptional Children was created to advocate for these students and create a more successful, less discriminatory form of education. Today there is a chapter of this council at Providence College. By the later 1920’sShow MoreRelatedThe Role Of Special Education For Children With Special Needs1289 Words   |  6 Pagesbehaviors. Children with disabilities may sometimes be seen as â€Å"different† by other children. This may lead to being excluded from peer relationships and experiences of social isolation. However, children with special needs may experience good mental health in supportive environments that support their strengths. I believe that children beneï ¬ t from having positive relationships and feel a sense of belonging at school. These positive experiences are important for children with special needs. Like allRead MoreEqual Education for Special Needs Children931 Words   |  4 Pagesreceive the proper help to get the education they desire. There shouldn’t be any separation between some students that have physical, mental, emotional, or no problem at all. There are children with variations of disabilities. The children with severe disabilities may not be able to get the equal education because it takes more effort than the ones with low levels of disability. As for the low-mild disabled children, they could be included in the classrooms with children that do not have a disabilityRead MoreThe Importance Of Education For Children With Special Needs Essay2395 Words   |  10 Pages Education is an important tool that is provided for young children to use in order to prepare themselves for their future, and this opportunity should be done so with the upmost respect and in the best interest of that child. When discussing education for a child, depending on that students needs there are two options, general education or special education. There are many different discussions occurring regarding if a child with special needs should be in a school that allows inclusion. I argueRead MoreSpecial Needs Children and the Special Education Program Controversy1409 Words   |  6 PagesSpecial education is such a broad and sensitive topic to talk about as well as the several issues that come with the Special education topic. And although there are a variety of issues, such as: special education children being accepted, segregated from their peers, the financial ability to support many special education programs, and the fact that a lot of teachers are not properly certified and do not know how to handle special needs children; there are also many resolutions. Special educationRead MoreWhy Education Is Important For Children With Special Needs1222 Words   |  5 PagesI believe education is one of the most important tools a person can have in life. Every child deserves to receive the best education possible, regardless of special needs. Being placed in the least restrictive environment, gaining necessary life skills and learning how to relate and communicate with people from different walks of life is imperative to the academic growth and success of any student. I have taught children with special needs in the Grand Rapids Public School district for nineteenRead MoreEducation And Education Of Children With Special Needs And Institutional Care Essay2008 Words   |  9 PagesONE: SPECIAL NEEDS PROVISION IN IRELAND THE ROLE OF RELIGIOUS ORDERS IN THE CARE AND EDUCATION OF CHILDREN WITH SPECIAL NEEDS AND INSTITUTIONAL CARE In Ireland the education of children with special needs has progressed through three phases: neglect and denial, special schools provision and integration and inclusion (Swan, 2000). The national Education system was set up in 1831 making school attendance compulsory but the government did not consider the education of children with special needs necessaryRead MoreThe Benefits of Virtual Technology in Education for Children with Special Needs1310 Words   |  6 Pages1.0 Introduction Education for children with special needs (disabled children) is the field of education that uses virtual reality to overcome the problems and defects in an artificial environment. Special education in Malaysia was started in 1920 by a handful of volunteers involved in the development of the deaf and blind school. There are three statutory bodies involved in the development of special education in Malaysia Ministry of Health, Ministry of National Unity and Development of the CommunityRead MoreInclusive Education For Children With Disabilities And Special Educational Needs2478 Words   |  10 PagesInclusive Education Introduction From many years, the topic of inclusive education has become a center of debates and discussions related to the educational practice and policy development around the globe (Farrell and Ainscow, 2002). Presently, the Education of youngsters and children with disabilities and special educational needs (SEN) is a well-recognized primary objective of policies in several countries (Lindsay, 2007). The policy and legislative trends from previous three to four decades haveRead MorePreparing Regular Education Teachers For Address The Diverse Needs Of Children With Special Needs2409 Words   |  10 PagesPreparing regular education teachers to address the diverse needs of children with special needs in inclusive set up. Rationale Sri Lanka has accepted inclusive education as a policy which shows different education reforms. Education reforms in 1997 supported the philosophy and practice of Inclusive Education. According to the concept of inclusive education, the responsibility of addressing the needs of all children has to be taken by regular education teachers. But the issues of addressing theRead MoreThe Importance Of Special Learning Needs For Children With Disabilities, And Different Processes / Aspects Of Special Education1111 Words   |  5 Pagesfrequently interacts with children with some form of disability. The purpose of this assignment is to gain a deeper understanding of students with disabilities, the individuals who interact with them, and different processes/aspects of special education. Amy Edwards - a special education teacher at McKinley Elementary located in Xenia, Ohio was interviewed. Ms. Edwards first became interested in special education at a young age. The pastor at her church had a daughter with special needs. Ms. Edwards had the

Monster Energy Drink - Marketing Strategy And Recommendation

Question: Explain about the monster energy drink. Answer: Introduction The beverage industry has been experiencing rapid growth in the business, in recent years. In the beverage industry, Monster energy drink is one of the most famous drinks. In April 2002, Hansen Natural Corp. (HANS) introduced the Monster energy drink. The mission of the company is to satisfy the needs of the company for superior quality. The mission of the company is to empower the customers for improving performance. In order to assist further augmentation the organization sustain customers trust (Monster Energy, 2016) Overview Internal (micro) Analysis The organization targeted mainly the young urban male and females. The income of the customers varies but they generally is on the middle range. The individuals apply for courageous and energizing way of life. Red bull is the primary threat for the brand and they mainly hold half of the market share (Tsarouhas, 2013). Hence, it can be identified that Monster energy has been growing its business.The main objective of the company is to satisfy the needs of the company. the motto which is utilized as a part of the battle for red bull is spreading for making brand familiarity with the item. External Analysis According to PESTEL analysis, the organization have safe, stable, least corrupted and business friendly environment. The analysis suggests that the organization have increased employment rate. The monster energy drink provides slow deflation and outlook growth. Local sponsorship is provided by the organization in major sports as per PESTEL (Chen, 2012). A survey was conducted by the organization in local preference. Advertisement was done on social media and mass media platforms. The order to understand the taste and monster energy drink collaborates with major supermarkets for recycle programs. PESTEL suggests strict rules and regulation. SWOT The monster energy drink provides reasonable price for bigger can of drinks. It has well known brands in as well as endorsement with number of celebrity. The organization creates more awareness by advertising on social media. The organization creates more innovative ideas. Brand awareness is low in Singapore, which is one of the most important weakness of the organization. The organization is facing stiff competition with other competitors. Health concern is one of the most important issues. Marketing strategy and recommendation The market of the organization focuses on consumer needs, their priorities and designing of the product. Demographic research inspects age, religion, gender, occupation etc. researchers have scrutinized market and they have reported that energy enhance performance level. Socio-economic strategy is important for assessing the potentiality of the customers. It is concluded that the organization promotes their market value through sports and adventures. Marketing Mix and Recommendation The Monster energy drinks are offered in different varieties and flavours. The monster zero ultra was initiated with less sweet and zero calories. They make their product unique from other brands in the market (Sacks et al., 2015). On the monster energy drink always provide affordable pricing policy for its customers and it became one of the most important reason behind the companys position in the market. The main aim of the company is to find the consumers at the right time at the right place in the right situation. The entry strategy of the company is based on exclusivity. Monster drink sometimes attracts its customers by offering free drinks. In my opinion, the company must extend or change its marketing strategy in order to compete with other energy brands. References Chen, L. F. (2012). A novel approach to regression analysis for the classification of quality attributes in the Kano model: an empirical test in the food and beverage industry.Omega,40(5), 651-659. Monster Energy. (2016).Monsterenergy.com. Retrieved 6 June 2016, Sacks, G., Mialon, M., Vandevijvere, S., Trevena, H., Snowdon, W., Crino, M., Swinburn, B. (2015). Comparison of food industry policies and commitments on marketing to children and product (re) formulation in Australia, New Zealand and Fiji.Critical Public Health,25(3), 299-319. Tsarouhas, P. H. (2013). Evaluation of overall equipment effectiveness in the beverage industry: a case study.International Journal of Production Research,51(2), 515-523.

Managing Financial Resources free essay sample

Unit 2: managing financial resources and decisions outcome 1: understand the sources of finance available to a business outcome 2. 4: explain the impact of finance on the financial statements outcome 3: make decision based on financial information outcome 4: analyze and evaluate the financial performance of a business scenario you have graduated from hnd with flying colors and have been successful at finding a job as a financial consultant with high finance consultancy ltd. Your job is to advise clients on diverse projects as and when they are handled by your firm. Please study each task and give your expert opinion Task 1 you have to advise rabeebok plc, a public limited company that manufactures sporting goods. The management of the organization is in the process of evaluating expansion plans. For this, you need to write a report on the following: 1. 1 p1- identify and discuss all the different sources of finance available to the company (max: 1200 words) 1. We will write a custom essay sample on Managing Financial Resources or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page 2 p2 -assess the implications of the different sources (max 1000 words) 1. 3 p3 evaluate appropriate sources of finance for rabeebok. Plc who needs to decide where to get specific funds for their particular expansion needs. These expansion plans will require capital for the following: a) additional land b) additional equipment c) a fleet of 10 staff transport vehicles d) day to day operations m1- while completing 1. 3 p3, demonstrate that effective judgments have been made. Justify why you think particular sources are suitable for each need m2-while completing 1. 1 p1, use at least two sources other than the textbook to complete your discussion on the sources of funds available to organizations. Include these references in the body of the discussion (i. E. In the assignment itself) as well as in the bibliography. This criterion is meant to encourage you to utilize a range of sources of information. D1-critically evaluate why at least two sources of funds are not suitable for each option in the scenario described in 1. 3 p3. This criterion is meant to encourage you to use critical reflection to generate and justify valid conclusions. Guidelines to achieve 1. 1 p1, 1. 2 p2 and 1. 3 p3: for 1. 1 p1, you must identify all the sources of funds that are available to a public limited company. These should include all internal and external sources which are available to all small, medium and large companies. For 1. 2 p2,you must discuss the advantages of using each different source of fund. For example, for hire purchase, you can mention that an advantage of using this source of funds is that there is no up front lump sum payment whereas one of the disadvantages is that the organization does not own the asset unless all the installments have been paid off. For 1. 3 p3,suggest appropriate sources of finance for these needs. You should consider the purpose for which the funds are required and which sources of funds will be most appropriate. Task 2 allisson and company is a wholesale business. Their budgeted income for the first six months of 2014 is as follows: jan 14 feb 14 mar 14 apr 14 may 14 jun14 sales 52 55 55 60 55 53 c. G. S 30 31 31 35 31 32 salaries 10 10 10 10 10 10 electricity 5 5 4 3 3 3 depreciation 3 3 3 3 3 3 other overheads 2 2 2 2 2 2 total expenses 50 51 50 53 49 50 net profit 2 4 5 7 6 3 all amounts shown are in ? 000 allisson and co. Gives all its customers one month credit. Sales revenue in dec 2013 is expected to be ? 60,000 inventory purchases are made on one month’s credit. December 2013 purchases are estimated to be ? 30,000. Salaries and other overheads are paid in the month concerned. Electricity is paid quarterly in march and june. The business plans to buy and pay for a new van in march. The cost of this van is ? 15000 the business plans to buy some equipment in april for ? 38000. The business expects to have a beginning balance of ? 12000 in cash in january 2014. 3. 1 p8 a) discuss the types of budgets that allisson and co will need to help in making financial decisions. B) based on the information provided to you, prepare a cash budget for allisson and co. For the first six months of 2014 and discuss any problems the company may face in these six months. C) make recommendations on how to improve cash balances over the six month period and make a new improved budget for this period d3 – demonstrate that a high level of creative thinking has been employed to solve allison and co’s cash budget problems. Task 3 3. 2 p9- do the required calculations and use this information to make pricing decisions. Information will be provided in class. This task will be completed as a time constrained class activity. Task 4 assess the viability of a project using investment appraisal techniques. Al haider contractors llc is investigating the possibility of investing in two new projects. Data have been extracted from the report relating to the projects. Both projects involve purchasing new equipment. The data will be provided to you in class at the time of the class activity as per the format below: project 1 (? ) project 2 (? ) cost expected annual net profit/(loss) year 1 year 2 year 3 the company has an estimated cost of capital of 10% and uses the straight line method of depreciation for all fixed assets when calculating net profits. The business has sufficient funds for all capital expenditure requirements. 3. 3 p10. Calculate for each project: a. Payback period b. Net present value c. Approximate internal rate of return compare the two projects and discuss which is more viable for the organization. Task 5 make a presentation with two other colleagues on the following: 2. 4 p7 – explain the impact of finance on the financial statements. 4. 1 p11 explain the purposes of the main financial statements . 4. 2 p12 describe the differences between the formats of financial statements for different types of businesses. M3 while making the presentation for 2. 4 p7, 3. 3 p10 and 4. 1 p11, ensure that technical language is accurately used. This will be assessed on an individual basis during the presentation D2 – while making the above presentation, take responsibility for managing and organizing activities of others. You will need to provide evidence of this in the form of action plans, minutes of meetings and if possible, discuss a conflict situation you have handled. Task 6 4. 3 p13 interpret financial statements using appropriate ratios and comparisons both internal and external. For this task, you will be evaluating the financial performance of two organizations using appropriate ratios and comparisons. The financial statements of the two organizations will be provided to you during a class activity.

Poseidon Essays - Greek Sea Gods, Titans, Mother Goddesses, Poseidon

Poseidon I just finished reading about the god Poseidon. I am going to tell you a little about him. Some of the things that I am going to tell you about, are some of his relatives, his symbol, his power, a few interesting facts, and a brief summary of one of the many stories that he is mentioned in. First I am going to tell you about his symbol. It is a trident. It was given to him by the Cyclopes to arm him in the battle against the Titans. The trident is not just something that looks like a pitchfork. It is much more powerful. It has the power to fork up whole continents and islands. After that, this became his tool of power. He would also throw his trident at the ground and it would create huge earthquakes. This is how he got his nickname Earthshaker. Now I am going to tell you about the relatives of Poseidon. His parents were Cronus and Rhea. Poseidon is the brother of Demeter, Hades, Hera, Hestia and Zeus. Zeus banished him to the underwater kingdom. Then Poseidon hurled huge waves at Zeus' kingdom on Mount Olympus. He was unable to reach the kingdom, so he threw the waves at the land. This eroded it everywhere except where Mother Earth put cliffs. Now I am going to tell you a summary of a myth about Poseidon. The name of this story is Poseidon. "In the days of Cronus and the Titans, the sea was ruled by Nereus." Nereus was the father of fifty sea nymphs. When Poseidon came to take over the sea, Nereus gave him his daughter Amphitrite for his queen. Then Nereus retired and went into an underwater grotto. Poseidon had a son with Amphitrite. His name was Triton. He had a fishtail instead of legs. Just like his grandfather. He rode around on the back of a sea monster. Poseidon was barely ever at home because he was always racing the waves with his snow white horses. Poseidon had many wives and many children but Amphitrite was not jealous. One of the islands that Poseidon made was named Delos. It was so new that it still floated about the ocean. The only thing that grew on this island was a palm tree. This island had barely been discovered. This is the island on which Apollo and Artemis would be born. This is why Apollo and Artemis will be born on the island of Delos. Hera found out that Zeus had married Leto. She got very mad and ordered all the lands to refuse to give her shelter. Therefore Leto could not give birth to the babies. She then went to Delos. They could accept her there because it was still floating and was not a land yet. But she still could not give birth to the babies because Hera had forbid Ilithyia the goddess of childbirth to go to her. "Without her help no child could be born." All the goddess' felt bad for Leto, so they bribed Hera with a necklace. It was nine feet long and made of gold and amber. Hera gave in and let Ilithyia go to Leto. Then Apollo and Artemis were born. "Zeus was filled with joy at the sight of his beautiful twins. He gave them each a silver bow and quiver full of arrows. The arrows of Artemis were soft as the moon and brought painless death, those of Apollo were hard and piercing as the rays of the sun." Zeus blessed the island and attached it to the bottom of the sea. Plants grew everywhere on the island and this island became the richest Greek island of all. "Pilgrims flocked to it and loaded it with temples and treasures to honor Leto and her Twins." That was just some of the many interesting facts that I found about Poseidon. Poseidon is just one of the many Greek gods. So think of all the interesting facts about Greek mythology there are. I hope that you enjoyed reading my report on Poseidon.

Microsoft Debate Essay

Microsoft Debate Essay Microsoft Debate Essay Name Bibles Microeconomics 10 February 2014 Microsoft Debate There was a debate over the status of Microsoft Corporation from a business standpoint. They supply the operating system to about ninety percent of computers but they do not have a clear-cut competitor when it comes to prices. Does this make them a monopoly? Do they purposefully keep prices low to discourage other computer companies from being able to compete with them? The question for lawmakers became: â€Å"Does Microsoft’s business strategy break any anti-trust laws?† Many different computer programs are automatically designed to be compatible with the Microsoft operating system. Personally, I don’t think that you can blame Microsoft for the actions of other computer programming companies. The inadvertent effect of the programming companies’ actions is that computer users are being encouraged to purchase Microsoft computers to ensure that their programs will be compatible. I don’t think this implication is enough to claim that Microsoft is a monopoly but the courts felt as if it was. Also, they are a good business where they do not totally take all of the business of the market and act as a total monopoly. Microsoft do almost have a complete control of the Operating System Market where almost 93% of computers are programmed with Windows instead of Mac OSX or a Linux Distro. Microsoft was charged with â€Å"1. Monopolizing the computer operating system market, 2. Integrating the Internet Explorer web browser into the operating system in an attempt to eliminate competition from Netscape, and 3. Using its market power to form anticompetitive agreements with producers of related goods,† (South-western College). Microsoft was said in court to be a monopoly and the decision of the judge and punishment was for Microsoft’s corporation to be split into two different corporations. One corporation would handle the operating system and the other corporation would handle the software and program development. This did not happen. Microsoft went through a series of appeals and their appeal even made it to the Supreme Court. Their appeal was denied by the Supreme Court and the Federal

Social Problem Essay Example | Topics and Well Written Essays - 500 words

Social Problem - Essay Example During the latest news reports appear to point out that Odessa has slightly controlled its fervor for football moreover has commenced to re-evaluate its main concern. The volume's advantage lies within the reality that, even as it features the excesses which occur inside Odessa because of the city's fascination through the Permian Panthers, the booklovers appreciates the authentic fervor the township, the coaches, as well as the team participants have intended for the sport. Although it is terrible to read regarding the city's disgust of Hispanics along with African Americans also its nearly complete derision for anything which interferes with football, Bissinger did well in moving us to root for the squad and interpret with bated breathing the narration of the team's victory on the sports ground. Midland has been pretty much the dead contrary of Odessa. Odessa has been considered as a working rank, affluent in boom together with dirt-poor into bust, filled with shotgun abodes and combating mean.